Article
From genetics of inflammatory bowel disease towards mechanistic insights.
Trends in immunology - 1 Aug 2013
Graham Daniel B, Xavier Ramnik J
Abstract excerpt
Advancements in human genetics now poise the field to illuminate the pathophysiology of complex genetic disease. In particular, genome-wide association studies (GWAS) have generated insights into the mechanisms driving inflammatory bowel disease (IBD) and implicated genes shared by multiple autoimmune and autoinflammatory diseases. Thus, emerging evidence suggests a central role for the mucosal immune system in...
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