Article
Natural resistance to HIV infection: The Vif-APOBEC interaction.
Comptes rendus biologies - 1 Nov 2006
Malim Michael H
Abstract excerpt
Members of the APOBEC family of cellular polynucleotide cytidine deaminases (e.g., APOBEC3G) are potent inhibitors of HIV infection. Wild type viral infections are largely spared from APOBEC function through the action of the viral Vif protein. In Vif's absence, inhibitory APOBEC proteins are encapsidated by budding virus particles leading to excessive cytidine (C) to uridine (U) hypermutation of negative sense...
Topics
- APOBEC-1 Deaminase
- Animals
- Cytidine Deaminase
- DNA, Complementary
- Deamination
- Gene Products, vif
- HIV Infections
- HIV-1
- Humans
- Immunity, Innate
- Mutation
- Phenotype