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Article

Experimental platform utilising melting curve technology for detection of mutations in Mycobacterium tuberculosis isolates.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 1 Jul 2018

Broda Agnieszka, Nikolayevskyy Vlad, Casali Nicki, Khan Huma, Bowker Richard, Blackwell Gemma, Patel Bhakti, Hume James, Hussain Waqar, Drobniewski Francis

Abstract excerpt

Tuberculosis (TB) remains one of the most deadly infections with approximately a quarter of cases not being identified and/or treated mainly due to a lack of resources. Rapid detection of TB or drug-resistant TB enables timely adequate treatment and is a cornerstone of effective TB management. We evaluated the analytical performance of a single-tube assay for multidrug-resistant TB (MDR-TB) on an experimental...

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Identifiers

PMID: 29675789
DOI: 10.1007/s10096-018-3246-2
PMCID: PMC6015100

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