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Article

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome

13 Apr 2018

Abstract excerpt

The NLRP3 inflammasome has an important function in inflammation by promoting the processing of pro-IL-1β and pro-IL-18 to their mature bioactive forms, and by inducing cell death via pyroptosis. Here we show a critical function of the E3 ubiquitin ligase Pellino2 in facilitating activation of the NLRP3 inflammasome. Pellino2-deficient mice and myeloid cells have impaired activation of NLRP3 in response to...

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PMID: 29674674
DOI: 10.1038/s41467-018-03669-z

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