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A Multi-Dimensional Approach to Map Disease Relationships Challenges Classical Disease Views.

Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2024

Möbus Lena, Serra Angela, Fratello Michele, Pavel Alisa, Federico Antonio, Greco Dario

Abstract excerpt

The categorization of human diseases is mainly based on the affected organ system and phenotypic characteristics. This is limiting the view to the pathological manifestations, while it neglects mechanistic relationships that are crucial to develop therapeutic strategies. This work aims to advance the understanding of diseases and their relatedness beyond traditional phenotypic views. Hence, the similarity among...

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PMID: 38840452
DOI: 10.1002/advs.202401754
PMCID: PMC11321629

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