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Chronic Mucocutaneous Candidiasis in Autoimmune Polyendocrine Syndrome Type 1

19 Nov 2018

Abstract excerpt

Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is an autosomal recessive disease caused by mutations in the autoimmune regulator (AIRE) gene, characterized by the clinical triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism, and adrenal insufficiency. CMC can be complicated by systemic candidiasis or oral squamous cell carcinoma (SCC), and may lead to death. The role of...

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PMID: 30510552
DOI: 10.3389/fimmu.2018.02570

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