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Article

Enriched variations in TEKT4 and breast cancer resistance to paclitaxel.

Nature communications - 13 May 2014

Jiang Yi-Zhou, Yu Ke-Da, Peng Wen-Ting, Di Gen-Hong, Wu Jiong, Liu Guang-Yu, Shao Zhi-Ming

Abstract excerpt

Among chemotherapeutic agents, paclitaxel has shown great efficacy against breast cancer. Prediction of paclitaxel response may improve patient outcomes. Here we show, using exome sequencing, that in comparison with pre-treatment biopsies, two TEKT4 germline variations are enriched in post-treatment tumours. We find TEKT4 variations in ~ 10% of an independent cohort of 84 pairs of samples. Tektin4 (encoded by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24823476
DOI: 10.1038/ncomms4802

Genes

TEKT4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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