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Article

Hypericin affects cancer side populations via competitive inhibition of BCRP.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2018

Vargová Jana, Mikeš Jaromír, Jendželovský Rastislav, Mikešová Lucia, Kuchárová Barbora, Čulka Ľubomír, Fedr Radek, Remšík Ján, Souček Karel, Kozubík Alois, Fedoročko Peter

Abstract excerpt

OBJECTIVE: Cancer stem-like cells (CSLCs) are considered a root of tumorigenicity and resistance. However, their identification remains challenging. The use of the side population (SP) assay as a credible marker of CSLCs remains controversial. The SP assay relies on the elevated activity of ABC transporters that, in turn, can be modulated by hypericin (HYP), a photosensitizer and bioactive compound of St. John's...

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PMID: 29665654
DOI: 10.1016/j.biopha.2018.01.074

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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