Article
Effects of Withania somnifera and Tinospora cordifolia extracts on the side population phenotype of human epithelial cancer cells: toward targeting multidrug resistance in cancer.
Integrative cancer therapies - 1 Mar 2015
Maliyakkal Naseer, Appadath Beeran Asmy, Balaji Sai A, Udupa Nayanabhirama, Ranganath Pai Sreedhara, Rangarajan Annapoorni
Abstract excerpt
Recent reports suggest the existence of a subpopulation of stem-like cancer cells, termed as cancer stem cells (CSCs), which bear functional and phenotypic resemblance with the adult, tissue-resident stem cells. Side population (SP) assay based on differential efflux of Hoechst 33342 has been effectively used for the isolation of CSCs. The drug resistance properties of SP cells are typically due to the increased...
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