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New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells

3 May 2023

Abstract excerpt

The presence of key hypoxia regulators, namely, hypoxia-inducible factor (HIF)-1α or HIF-2α, in tumors is associated with poor patient prognosis. Hypoxia massively activates several genes, including the one encoding the BCRP transporter that proffers multidrug resistance to cancer cells through the xenobiotic efflux and is a determinant of the side population (SP) associated with cancer stem-like phenotypes. As...

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PMID: 37146419
DOI: 10.1016/j.biopha.2023.114829

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