Integrative computational analysis of Marburg virus protein mutations: structural and functional implications of Glycoprotein variants and natural inhibitor screening.

Abstract excerpt

Marburg virus is a highly virulent filovirus responsible for severe hemorrhagic fever outbreaks with high mortality rates. This study aimed to (1) investigate the structural and functional consequences of mutations in major MARV proteins-particularly Glycoprotein (GP)-and (2) evaluate the antiviral potential of selected plant-derived compounds using computational approaches. Comparative sequence analysis...

Topics

• Marburgvirus
• Molecular Dynamics Simulation
• Mutation
• Molecular Docking Simulation
• Antiviral Agents
• Glycoproteins