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Article

Compression Fractures and Partial Phenotype Rescue With a Low Phosphorus Diet in the Chihuahua Zebrafish Osteogenesis Imperfecta Model.

Frontiers in endocrinology - 1 Jan 2022

Cotti Silvia, Huysseune Ann, Larionova Daria, Koppe Wolfgang, Forlino Antonella, Witten Paul Eckhard

Abstract excerpt

Osteogenesis imperfecta (OI) is a group of heritable disorders affecting bone and other connective tissues. Dominant OI forms are mainly caused by mutations in collagen type I. Patients suffer from skeletal deformities, fractures of long bones and vertebral compression fractures from early childhood onward. Altered collagen structure and excess mineralisation are the main causes for the bone phenotype. The...

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Identifiers

PMID: 35282456
DOI: 10.3389/fendo.2022.851879
PMCID: PMC8913339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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