Article
Col1A-2 Mutation in Osteogenesis Imperfecta Mice Contributes to Long Bone Fragility by Modifying Cell-Matrix Organization.
International journal of molecular sciences - 30 Nov 2023
André Grégoire, Chretien Antoine, Demoulin Antoine, Beersaerts Mélanie, Docquier Pierre-Louis, Behets Catherine
Abstract excerpt
Osteogenesis imperfecta (OI) is a rare congenital bone dysplasia generally caused by a mutation of one of the type I collagen genes and characterized by low bone mass, numerous fractures, and bone deformities. The collagen organization and osteocyte lacuna arrangement were investigated in the long bones of 17-week-old wildtype (WT, n = 17) and osteogenesis imperfecta mice (OIM, n = 16) that is a validated model...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.