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Article

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance.

Nature reviews. Cancer - 1 Jun 2018

Katzenellenbogen John A, Mayne Christopher G, Katzenellenbogen Benita S, Greene Geoffrey L, Chandarlapaty Sarat

Abstract excerpt

Oestrogen receptor-α (ERα), a key driver of breast cancer, normally requires oestrogen for activation. Mutations that constitutively activate ERα without the need for hormone binding are frequently found in endocrine-therapy-resistant breast cancer metastases and are associated with poor patient outcomes. The location of these mutations in the ER ligand-binding domain and their impact on receptor conformation...

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Share to Androgen Antagonists
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Estrogen Receptor alpha

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Source

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Identifiers

PMID: 29662238
DOI: 10.1038/s41568-018-0001-z
PMCID: PMC6252060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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