Article
Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer.
Molecular cancer research : MCR - 1 Sept 2021
Mayne Christopher G, Toy Weiyi, Carlson Kathryn E, Bhatt Trusha, Fanning Sean W, Greene Geoffrey L, Katzenellenbogen Benita S, Chandarlapaty Sarat, Katzenellenbogen John A, Tajkhorshid Emad
Abstract excerpt
Although most primary estrogen receptor (ER)-positive breast cancers respond well to endocrine therapies, many relapse later as metastatic disease due to endocrine therapy resistance. Over one third of these are associated with mutations in the ligand-binding domain (LBD) that activate the receptor independent of ligand. We have used an array of advanced computational techniques rooted in molecular dynamics...
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