Article
Vav1 downmodulates Akt in different breast cancer subtypes: a new promising chance to improve breast cancer outcome.
Molecular oncology - 1 Jun 2018
Grassilli Silvia, Brugnoli Federica, Lattanzio Rossano, Marchisio Marco, Perracchio Letizia, Piantelli Mauro, Bavelloni Alberto, Capitani Silvano, Bertagnolo Valeria
Abstract excerpt
Targeting different members of the Akt pathways is a promising therapeutic chance in solid tumors including breast cancer. The variable expression levels of Akt isoforms with opposite effects on tumor growth and metastasis, however, make it difficult to select the inhibitors to be used for specific breast tumor subtypes. Using in vitro and in vivo models, we demonstrated here that Vav1, ectopically expressed in...
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