[Abnormalities of signal transduction molecules in multiple myeloma].

Abstract excerpt

Although the recent advances in therapeutic drugs have improved outcomes for multiple myeloma, this disease remains incurable. One of the most commonly detected genetic abnormalities in myeloma is the activating oncogenic mutation of KRAS and NRAS in MAP kinase pathway. New technologies, such as next generation sequencing, have revealed an activating mutation in BRAF, as well; this mutation is observed in a half...

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