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The study on polymorphisms of Sep15 and TrxR2 and the expression of AP-1 signaling pathway in Kashin-Beck disease.

Bone - 1 Mar 2019

Wu RuiPeng, Zhang RongQiang, Xiong YongMin, Sun WenYan, Li YuanYuan, Yang XiaoLi, Liu JiFeng, Jiang Yong, Guo Hao, Mo XiaoYan, Cao JunLing

Abstract excerpt

The aim of the study was to investigate the association between rs5859 in Sep15, rs1139793 in TrxR2 polymorphisms with the risks of KBD and to detect the expression of AP-1 pathway in KBD subjects and in vitro. 208 KBD and 206 control subjects were included. PCR-Restriction Fragment Length Polymorphism (RFLP), Amplification Refractory Mutation Specific-PCR (ARMS-PCR) and Western Blotting were conducted. The...

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PMID: 29653292
DOI: 10.1016/j.bone.2018.03.026

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