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The effect of DNA repair gene variants on COVID-19 disease: susceptibility, severity, and clinical course.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2023

Senkal Naci, Serin Istemi, Pehlivan Sacide, Pehlivan Mustafa, Medetalibeyoglu Alpay, Cebeci Timurhan, Konyaoglu Hilal, Oyacı Yasemin, Sayın Gozde Yesil, Isoglu-Alkac Ummuhan, Tukek Tufan, Kose Murat

Abstract excerpt

Oxidative stress (OS), which leads to DNA damage, plays a role in the pathogenesis of Coronavirus disease 2019 (COVID-19). We aimed to evaluate the role of DNA repair gene variants [X-ray repair cross complementing 4 (XRCC4) rs28360071, rs6869366, and X-ray cross-complementary gene 1 (XRCC1) rs25487] in susceptibility to COVID-19 in a Turkish population. We also evaluated its effect on the clinical course of the...

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PMID: 36708261
DOI: 10.1080/15257770.2023.2172183

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