Article
Genetic variants in the HLA-DRB1 gene are associated with Kashin-Beck disease in the Tibetan population.
Arthritis and rheumatism - 1 Nov 2011
Shi Yi, Lu Fang, Liu Xin, Wang Yao, Huang Lulin, Liu Xiaoqi, Long Wubin, Lv Bo, Zhang Kun, Ma Shi, Lin He, Cheng Jing, Zhou Bin, Hu Mei, Deng Jiayun, Zhu Jianxin, Hao Peng, Yang Xiao, Zeng Mingcai, Wang Xiaoquan, Shen Sikui, Yang Zhenglin
Abstract excerpt
OBJECTIVE: To investigate the association between variants in the HLA-DRB1 gene and Kashin-Beck disease (KBD), as well as associations of selenium and iodine deficiencies with KBD in a Tibetan population. METHODS: Fourteen single-nucleotide polymorphisms (SNPs) were genotyped around the HLA-DRB1 gene, and HLA-DRB1 allele genotyping was performed in a discovery cohort, composed of 605 patients with KBD and 393...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.