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Article

SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease.

The British journal of nutrition - 1 Jan 2012

Du Xiao Hong, Dai Xiao Xia, Xia Song Rui, Zou Xiu Zhen, Yan Sun Wen, Mo Xiao Yan, Lu Bai Guang, Xiong Yong Min

Abstract excerpt

Kashin-Beck disease (KBD) is a chronic endemic osteoarthropathy, which mainly occurs in West and Northeast China. Epidemiological studies suggest that Se deficiency is an important environmental factor for the incidence of KBD. Glutathione peroxidase 4 (GPx4) belongs to the glutathione peroxidase family, which is crucial for optimal antioxidant defences. Our purpose is to investigate the putative association...

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PMID: 21733339
DOI: 10.1017/S0007114511002704

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