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Article

Mutant CTNNB1 and histological heterogeneity define metabolic subtypes of hepatoblastoma.

EMBO molecular medicine - 1 Nov 2017

Crippa Stefania, Ancey Pierre-Benoit, Vazquez Jessica, Angelino Paolo, Rougemont Anne-Laure, Guettier Catherine, Zoete Vincent, Delorenzi Mauro, Michielin Olivier, Meylan Etienne

Abstract excerpt

Hepatoblastoma is the most common malignant pediatric liver cancer. Histological evaluation of tumor biopsies is used to distinguish among the different subtypes of hepatoblastoma, with fetal and embryonal representing the two main epithelial components. With frequent CTNNB1 mutations, hepatoblastoma is a Wnt/β-catenin-driven malignancy. Considering that Wnt activation has been associated with tumor metabolic...

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Source

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Identifiers

PMID: 28923827
DOI: 10.15252/emmm.201707814
PMCID: PMC5666308

Genes

CTNNB1
TCF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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