Article
UXT is required for spermatogenesis in mice.
PloS one - 1 Jan 2018
Schafler Eric D, Thomas Phillip A, Ha Susan, Wang Yu, Bermudez-Hernandez Keria, Tang Zuojian, Fenyö David, Vigodner Margarita, Logan Susan K
Abstract excerpt
Male mammals must simultaneously produce prodigious numbers of sperm and maintain an adequate reserve of stem cells to ensure continuous production of gametes throughout life. Failures in the mechanisms responsible for balancing germ cell differentiation and spermatogonial stem cell (SSC) self-renewal can result in infertility. We discovered a novel requirement for Ubiquitous Expressed Transcript (UXT) in...
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