Article
Characterization of the phylogenetic distribution and chromosomal insertion sites of five IS6110 elements in Mycobacterium tuberculosis: non-random integration in the dnaA-dnaN region.
Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease - 1 Jan 1998
Kurepina N E, Sreevatsan S, Plikaytis B B, Bifani P J, Connell N D, Donnelly R J, van Sooligen D, Musser J M, Kreiswirth B N
Abstract excerpt
SETTING: Five IS6110 chromosomal insertion sites were characterized in the multidrug resistant Mycobacterium tuberculosis 'W' strain. OBJECTIVE: To use insertion site probes to study the phylogenetic distribution of IS6110 in the M. tuberculosis genome. DESIGN: A total of 722 M. tuberculosis isolates, previously genotyped using the standard IS6110 Southern blot hybridization methodology, were re-hybridized with...
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