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Article

Targeting NAD+/PARP DNA Repair Pathway as a Novel Therapeutic Approach to SDHB-Mutated Cluster I Pheochromocytoma and Paraganglioma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2018

Pang Ying, Lu Yanxin, Caisova Veronika, Liu Yang, Bullova Petra, Huynh Thanh-Truc, Zhou Yiqiang, Yu Di, Frysak Zdenek, Hartmann Igor, Taïeb David, Pacak Karel, Yang Chunzhang

Abstract excerpt

Purpose: Cluster I pheochromocytomas and paragangliomas (PCPGs) tend to develop malignant transformation, tumor recurrence, and multiplicity. Transcriptomic profiling suggests that cluster I PCPGs and other related tumors exhibit distinctive changes in the tricarboxylic acid (TCA) cycle, the hypoxia signaling pathway, mitochondrial electron transport chain, and methylation status, suggesting that therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29636359
DOI: 10.1158/1078-0432.CCR-17-3406
PMCID: PMC7446242

Genes

SDHB
PARP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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