Article
Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence.
Acta neuropathologica - 1 Jun 2018
Katz Leah M, Hielscher Thomas, Liechty Benjamin, Silverman Joshua, Zagzag David, Sen Rajeev, Wu Peter, Golfinos John G, Reuss David, Neidert Marian Christoph, Wirsching Hans-Georg, Baumgarten Peter, Herold-Mende Christel, Wick Wolfgang, Harter Patrick N, Weller Michael, von Deimling Andreas, Snuderl Matija, Sen Chandra, Sahm Felix
Abstract excerpt
Epigenetic patterns on the level of DNA methylation have already been shown to separate clinically relevant subgroups of meningiomas. We here set out to identify potential prognostic implications of epigenetic modification on the level of histones with focus on H3K27 trimethylation (H3K27me3). H3K27me3 was assessed by immunohistochemistry on 232 meningiomas from 232 patients. In 194 cases, trimethylation was...
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