BRAF and c-kit gene copy number in mutation-positive malignant melanoma.

doi:10.1016/j.humpath.2006.01.003

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BRAF and c-kit gene copy number in mutation-positive malignant melanoma.

Human pathology - 1 May 2006

Willmore-Payne Carlynn, Holden Joseph A, Hirschowitz Sharon, Layfield Lester J

Abstract excerpt

Activating mutations in BRAF or c-kit have been reported in malignant melanoma. Because the activating mutations are dominant, it has been assumed that they are heterozygous in the affected tumors. To test this, we have carefully examined the DNA sequencing electropherograms on 43 BRAF mutation-p...

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BRAF and c-kit gene copy number in mutation-positive malignant melanoma.

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