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Berberine ameliorates β-amyloid pathology, gliosis, and cognitive impairment in an Alzheimer's disease transgenic mouse model.

Neurobiology of aging - 1 Dec 2012

Durairajan Siva Sundara Kumar, Liu Liang-Feng, Lu Jia-Hong, Chen Lei-Lei, Yuan Qiuju, Chung Sookja K, Huang Ling, Li Xing-Shu, Huang Jian-Dong, Li Min

Abstract excerpt

The accumulation of β-amyloid (Aβ) peptide derived from abnormal processing of amyloid precursor protein (APP) is a common pathological hallmark of Alzheimer's disease (AD) brains. In this study, we evaluated the therapeutic effect of berberine (BBR) extracted from Coptis chinensis Franch, a Chinese medicinal herb, on the neuropathology and cognitive impairment in TgCRND8 mice, a well established transgenic mouse...

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Identifiers

PMID: 22459600
DOI: 10.1016/j.neurobiolaging.2012.02.016

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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