Article
A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers.
Cancer cell - 9 Apr 2018
Berger Ashton C, Korkut Anil, Kanchi Rupa S, Hegde Apurva M, Lenoir Walter, Liu Wenbin, Liu Yuexin, Fan Huihui, Shen Hui, Ravikumar Visweswaran, Rao Arvind, Schultz Andre, Li Xubin, Sumazin Pavel, Williams Cecilia, Mestdagh Pieter, Gunaratne Preethi H, Yau Christina, Bowlby Reanne, Robertson A Gordon, Tiezzi Daniel G, Wang Chen, Cherniack Andrew D, Godwin Andrew K, Kuderer Nicole M, Rader Janet S, Zuna Rosemary E, Sood Anil K, Lazar Alexander J, Ojesina Akinyemi I, Adebamowo Clement, Adebamowo Sally N, Baggerly Keith A, Chen Ting-Wen, Chiu Hua-Sheng, Lefever Steve, Liu Liang, MacKenzie Karen, Orsulic Sandra, Roszik Jason, Shelley Carl Simon, Song Qianqian, Vellano Christopher P, Wentzensen Nicolas, Weinstein John N, Mills Gordon B, Levine Douglas A, Akbani Rehan
Abstract excerpt
We analyzed molecular data on 2,579 tumors from The Cancer Genome Atlas (TCGA) of four gynecological types plus breast. Our aims were to identify shared and unique molecular features, clinically significant subtypes, and potential therapeutic targets. We found 61 somatic copy-number alterations (SCNAs) and 46 significantly mutated genes (SMGs). Eleven SCNAs and 11 SMGs had not been identified in previous TCGA...
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