Article
Thymoquinone Attenuates Aluminum Chloride-Induced Testicular Injury by Inhibiting NLRP3/Caspase 1/IL-1β Inflammasome Signaling and Polarizing the Macrophages Toward Anti-Inflammatory M2 Phenotype.
Cells - 1 Dec 2025
Elhessy Heba M, Khattab Basma Adel, Badawy Alaa M, Elsayed Hassan Reda Hassan, Alghamdi Mansour A, Zafrah Hind, Rabei Mohammed R, Habotta Ola A, Lashine Nermeen H
Abstract excerpt
In recent decades, the quantity of sperm and the quality of semen have decreased, causing an increased incidence of male infertility. The increased exposure to environmental pollutants and metals, including aluminum, is one of the causes. Aluminum is reported to activate the proinflammatory macrophages and the NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome pathway in many organs. Thymoquinone...
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