Article
Increased autophagy blocks HER2-mediated breast tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 17 Apr 2018
Vega-Rubín-de-Celis Silvia, Zou Zhongju, Fernández Álvaro F, Ci Bo, Kim Min, Xiao Guanghua, Xie Yang, Levine Beth
Abstract excerpt
Allelic loss of the autophagy gene, beclin 1/BECN1, increases the risk of patients developing aggressive, including human epidermal growth factor receptor 2 (HER2)-positive, breast cancers; however, it is not known whether autophagy induction may be beneficial in preventing HER2-positive breast tumor growth. We explored the regulation of autophagy in breast cancer cells by HER2 in vitro and the effects of genetic...
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