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Article

Early Treatment and IL1RN Single-Nucleotide Polymorphisms Affect Response to Anakinra in Systemic Juvenile Idiopathic Arthritis.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2021

Pardeo Manuela, Rossi Marianna Nicoletta, Pires Marafon Denise, Sacco Emanuela, Bracaglia Claudia, Passarelli Chiara, Caiello Ivan, Marucci Giulia, Insalaco Antonella, Perrone Chiara, Tulone Anna, Prencipe Giusi, De Benedetti Fabrizio

Abstract excerpt

OBJECTIVE: To evaluate the impact of early treatment and IL1RN genetic variants on the response to anakinra in systemic juvenile idiopathic arthritis (JIA). METHODS: Response to anakinra was defined as achievement of clinically inactive disease (CID) at 6 months without glucocorticoid treatment. Demographic, clinical, and laboratory characteristics of 56 patients were evaluated in univariate and multivariate...

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PMID: 33615724
DOI: 10.1002/art.41612

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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