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Article

Exome array analysis of adverse reactions to fluoropyrimidine-based therapy for gastrointestinal cancer.

PloS one - 1 Jan 2018

Traylor Matthew, Walker Jemma L, Corrigan Adele A, Hernandez Monica A, Newhouse Stephen J, Folarin Amos A, Patel Hamel, Ross Paul J, Sanderson Jeremy D, Spicer James, Prescott Natalie J, Mathew Christopher G, Marinaki Anthony M, Lewis Cathryn M

Abstract excerpt

Fluoropyrimidines, including 5-fluororacil (5FU) and its pro-drug Capecitabine, are the common treatment for colorectal, breast, neck and head cancers-either as monotherapy or in combination therapy. Adverse reactions (ADRs) to the treatment are common and often result in treatment discontinuation or dose reduction. Factors contributing to ADRs, including genetic variation, are poorly characterized. We performed...

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Share to Antimetabolites, Antineoplastic
Share to Drug-Related Side Effects and Adverse Reactions

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gastrointestinal Neoplasms

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 29715290
DOI: 10.1371/journal.pone.0188911
PMCID: PMC5929530

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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