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Article

The Herc1 gene in neurobiology.

Gene - 10 Mar 2022

Lalonde Robert, Strazielle Catherine

Abstract excerpt

The function of the HERC1 gene has mainly been delineated by studying Herc1tbl (tambaleante) mutant mice, characterized by losses in cerebellar Purkinje cells, a lower number of synaptic vesicles in the hippocampus, and anomalies in climbing fiber projections from the inferior olive as well as alpha-motoneuron projections to the skeletal muscle. The salient behavioral phenotypes include cerebellar ataxia, a loss...

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PMID: 34990797
DOI: 10.1016/j.gene.2021.146144

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