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Article

Progressive Purkinje cell degeneration in tambaleante mutant mice is a consequence of a missense mutation in HERC1 E3 ubiquitin ligase.

PLoS genetics - 1 Dec 2009

Mashimo Tomoji, Hadjebi Ouadah, Amair-Pinedo Fabiola, Tsurumi Toshiko, Langa Francina, Serikawa Tadao, Sotelo Constantino, Guénet Jean-Louis, Rosa Jose Luis

Abstract excerpt

The HERC gene family encodes proteins with two characteristic domains: HECT and RCC1-like. Proteins with HECT domains have been described to function as ubiquitin ligases, and those that contain RCC1-like domains have been reported to function as GTPases regulators. These two activities are essen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20041218
DOI: 10.1371/journal.pgen.1000784
PMCID: PMC2791161

Genes

HERC1
RCC1
HERC3
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20041218-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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