Article
Impact of hydroxycarbamide and interferon-α on red cell adhesion and membrane protein expression in polycythemia vera.
Haematologica - 1 Jun 2018
Brusson Mégane, De Grandis Maria, Cochet Sylvie, Bigot Sylvain, Marin Mickaël, Leduc Marjorie, Guillonneau François, Mayeux Patrick, Peyrard Thierry, Chomienne Christine, Le Van Kim Caroline, Cassinat Bruno, Kiladjian Jean-Jacques, El Nemer Wassim
Abstract excerpt
Polycythemia vera is a chronic myeloproliferative neoplasm characterized by the JAK2V617F mutation, elevated blood cell counts and a high risk of thrombosis. Although the red cell lineage is primarily affected by JAK2V617F, the impact of mutated JAK2 on circulating red blood cells is poorly documented. Recently, we showed that in polycythemia vera, erythrocytes had abnormal expression of several proteins...
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