Article

Deciphering the complex clonal heterogeneity of polycythemia vera and the response to interferon alpha

2023-10-27

Abstract excerpt

<h4>Background: </h4> Interferon alpha (IFNa) is approved for the therapy of patients (pts) with polycythemia vera (PV), a subtype of myeloproliferative neoplasms (MPN), achieving high hematologic response (HR) rates. A fraction of pts also achieve molecular responses (MR), but clonal factors sensitizing for MR remain elusive. <h4>Methods: </h4>: We integrated colony formation and differentiation assays with sing...

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Literature Corpus work: 8e3a1cb9-be7b-531f-b5f0-384f22a40e7e
DOI: 10.21203/rs.3.rs-3490651/v1

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