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Article

Smooth-to-rough morphotype switching, a mechanism of phage resistance in Mycobacterium abscessus.

Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2026

Liew Jun Hao, Norman Ayuni, Illouz Morgane, Teo Teck-Hui, Ponti Riccardo Delli, Hamela Claire, Mohan Lalit, Lew Renee, Ron Chanvutha, Low Kay En, Daher Wassim, Chiam Aryeh, Maw Joanna, Sun Yan, Sorayah Ria, Oehlers Stefan H, Jhun Byung Woo, Teo Jeanette W P, Goulet Adeline, Bonne Isabelle, Wintjens René, Pethe Kevin, Huber Roland G, Kremer Laurent, Bifani Pablo

Abstract excerpt

Mycobacterium abscessus infections represent a growing global health concern due to their severe pathology and difficulty of treatment, largely driven by their intrinsic antimicrobial resistance. While phage therapy has emerged as a promising alternative approach, studies have predominantly focused on glycopeptidolipids (GPL)-deficient M. abscessus rough variants instead of the GPL-producing smooth variants...

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PMID: 41811441
DOI: 10.1073/pnas.2531197123
PMCID: PMC12993973

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