Article
Genetic factors that contribute to interindividual variations in plasma low density lipoprotein-cholesterol levels.
Ciba Foundation symposium - 1 Jan 1996
Cohen J, Gaw A, Barnes R I, Landschulz K T, Hobbs H H
Abstract excerpt
The interplay of multiple genes and environmental factors generates interindividual variation in plasma low density lipoprotein-cholesterol (LDL-C) concentrations. As a result, it has been difficult to identify individual genes that contribute to variation in plasma LDL-C levels using classical linkage analysis. We have exploited a genetic defect in the gene encoding the LDL receptor that is associated with a...
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