Article
Genome Editing in Neuroepithelial Stem Cells to Generate Human Neurons with High Adenosine-Releasing Capacity.
Stem cells translational medicine - 1 Jun 2018
Poppe Daniel, Doerr Jonas, Schneider Marion, Wilkens Ruven, Steinbeck Julius A, Ladewig Julia, Tam Allison, Paschon David E, Gregory Philip D, Reik Andreas, Müller Christa E, Koch Philipp, Brüstle Oliver
Abstract excerpt
As a powerful regulator of cellular homeostasis and metabolism, adenosine is involved in diverse neurological processes including pain, cognition, and memory. Altered adenosine homeostasis has also been associated with several diseases such as depression, schizophrenia, or epilepsy. Based on its protective properties, adenosine has been considered as a potential therapeutic agent for various brain disorders....
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