Article
Polymer nanofiber-based microchips for EGFR mutation analysis of circulating tumor cells in lung adenocarcinoma.
International journal of nanomedicine - 1 Jan 2018
Jiang Wenting, Wang Han, Cui Yongmei, Lei Yiyan, Wang Yuefeng, Xu Di, Jiang Neng, Chen Yangshan, Sun Yu, Zhang Yang, Cao Jessica, Ke Zunfu
Abstract excerpt
BACKGROUND: Circulating tumor cells (CTCs) detection, an approach considered to be "liquid biopsy", is a potential alternative method in clinical use for early diagnosis of solid tumor progression. METHODS: In this study, we developed a poly (lactic-co-glycolic acid) (PLGA) - nanofiber (PN)-NanoVelcro chip as an efficient device for simple and rapid capture of CTCs from peripheral blood. We evaluated the device...
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