Neonatal exposure to hyperoxia leads to persistent disturbances in pulmonary histone signatures associated with NOS3 and STAT3 in a mouse model

Abstract excerpt

Background: Early pulmonary oxygen exposure is one of the most important factors implicated in the development of bronchopulmonary dysplasia (BPD). Methods: Here, we analyzed short- and long-term effects of neonatal hyperoxia on NOS3 and STAT3 expression and corresponding epigenetic signatures using a hyperoxia-based mouse model of BPD. Results: Early hyperoxia exposure led to a significant increase in NOS3...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Congenital Diaphragmatic Hernia Studies
• Share to Neonatal Respiratory Health Research
• Share to Respiratory Support and Mechanisms