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Article

Epigenetic regulation of the endothelial nitric oxide synthase gene in persistent pulmonary hypertension of the newborn rat

18 Aug 2010

Abstract excerpt

OBJECTIVE: Persistent pulmonary hypertension of the newborn (PPHN) is a major clinical problem. Nitric oxide produced by endothelial nitric oxide synthase (eNOS) in endothelial cells plays an important role in the pathogenesis of PPHN. The eNOS expression in endothelial cells is controlled by epigenetic regulation. The aim of this study was to investigate the epigenetic regulatory mechanisms of the eNOS gene in...

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Share to Neonatal Respiratory Health Research
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PMID: 20724942
DOI: 10.1097/hjh.0b013e32833e08f1

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