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Article

Genomic and transcriptional alterations in mouse fetus liver after transplacental exposure to cigarette smoke

22 Apr 2003

Abstract excerpt

The transplacental exposure of fetuses to maternal cigarette smoke may increase the risk of developmental impairments, congenital diseases, and childhood cancer. The whole-body exposure of Swiss mice to environmental cigarette smoke (ECS) during pregnancy decreased the number of fetuses per dam, placenta weight, and fetus weight. ECS increased DNA adducts, oxidative nucleotide alterations, and cytogenetic damage...

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PMID: 12709406
DOI: 10.1096/fj.02-0967fje

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