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Article

Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs.

Molecular oncology - 1 May 2018

Tu Chih-Yen, Cheng Fang-Ju, Chen Chuan-Mu, Wang Shu-Ling, Hsiao Yu-Chun, Chen Chia-Hung, Hsia Te-Chun, He Yu-Hao, Wang Bo-Wei, Hsieh I-Shan, Yeh Yi-Lun, Tang Chih-Hsin, Chen Yun-Ju, Huang Wei-Chien

Abstract excerpt

Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it remains undetermined whether and how cigarette smoke affects the therapeutic efficacy of EGFR TKIs. In this study, our data showed that chronic exposure to cigarette smoke extract (CSE)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29570930
DOI: 10.1002/1878-0261.12193
PMCID: PMC5928373

Genes

EGFR
MET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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