Article
Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment.
Toxicological sciences : an official journal of the Society of Toxicology - 1 Aug 2010
Martínez-García Eva, Irigoyen Marta, González-Moreno Oscar, Corrales Leticia, Teijeira Alvaro, Salvo Elizabeth, Rouzaut Ana
Abstract excerpt
Cigarette smoking is strongly correlated with the onset of lung cancer. Nicotine, a major component in cigarette smoke, has been found to promote tumor growth and angiogenesis, as well as protect cancer cells from apoptosis. Among all lung cancer cases, small cell lung cancer (SCLC) is found almo...
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