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Article

Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells.

Molecular cancer therapeutics - 1 Aug 2013

Filosto Simone, Baston David S, Chung Samuel, Becker Cathleen R, Goldkorn Tzipora

Abstract excerpt

The EGF receptor (EGFR) is a proto-oncogene commonly dysregulated in several cancers including non-small cell lung carcinoma (NSCLC) and, thus, is targeted for treatment using tyrosine kinase inhibitors (TKI) such as erlotinib. However, despite the efficacy observed in patients with NSCLC harboring oncogenic variants of the EGFR, general ineffectiveness of TKIs in patients with NSCLC who are current and former...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23686837
DOI: 10.1158/1535-7163.MCT-12-1029
PMCID: PMC4370317

Genes

EGFR
EGF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells.PMID 23686837Read ↗

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