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Article

Cigarette smoke extract exposure induces EGFR-TKI resistance in EGFR-mutated NSCLC via mediating Src activation and EMT.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2016

Li Dandan, Zhang Lu, Zhou Junhao, Chen Hong

Abstract excerpt

OBJECTIVES: The study aims to explore the molecular basis for the poor response of epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) in EGFR mutated non-small cell lung cancer (NSCLC) patients with smoking history. Novel agent overcoming EGFR-TKI resistance had also been investigated. METHODS: The impact of cigarette smoke extract (CSE) on gefitinib sensitive PC-9 cells was evaluated using...

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Source

Identifiers

PMID: 26898612
DOI: 10.1016/j.lungcan.2015.12.007

Genes

EGFR
CCK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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