Article
The multiple paths towards MET receptor addiction in cancer.
Oncogene - 1 Jun 2018
Duplaquet Leslie, Kherrouche Zoulika, Baldacci Simon, Jamme Philippe, Cortot Alexis B, Copin Marie-Christine, Tulasne David
Abstract excerpt
Targeted therapies against receptor tyrosine kinases (RTKs) are currently used with success on a small proportion of patients displaying clear oncogene activation. Lung cancers with a mutated EGFR provide a good illustration. The efficacy of targeted treatments relies on oncogene addiction, a situation in which the growth or survival of the cancer cells depends on a single deregulated oncogene. MET, a member of...
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