Article
The characteristics of ctDNA reveal the high complexity in matching the corresponding tumor tissues.
BMC cancer - 23 Mar 2018
Yang Nong, Li Yi, Liu Zhidong, Qin Hao, Du Duanming, Cao Xinkai, Cao Xiaoqing, Li Jun, Li Dongge, Jiang Bo, Duan Lincan, Yang Haiyan, Zhang Zhenghua, Lin Hao, Li Jianying, Yang Zhenhua, Xiong Lei, Shen Hua, Lin Lizhu, Li Fugen
Abstract excerpt
BACKGROUND: Next-generation sequencing (NGS) is an efficient and sensitive method to detect mutations from ctDNA. Many features and clinical conditions could significantly affect the concordance between ctDNA and corresponding tumor tissues. Our goal was to systematically investigate the critical factors contributing to different concordance between ctDNA and corresponding tumor tissues. METHODS: We recruited two...
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